The winner of “National Excellent Young Scientists Fund” in 2015, and currently the Vice-Director of “National Key Laboratory of Biochemical Engineering”. Received the B.S. in Polymer Materials and the M.S. in Materials of Tianjin University, China, and the Ph.D. in Life Science of University of Strasbourg, France. The “Gene Medical Formulation and Engineering” research group was established, which has been focusing on the frontiers and key scientific issues like the bottlenecks restricting the success of gene therapy/nucleic acid vaccines. Through the rational design of biomaterial molecules, the variation features of the molecular structure and function of biomaterials corresponding to microenvironment changes were discovered, and the possibilities and mechanisms of effective regulation progress towards genetic drugs efficacy/nucleic acid vaccines immunity were demonstrated, thereby the research direction that the delivery of gene drugs/ nucleic acid vaccines with our characteristics was established. The membership of Editorial Board of Theranostics and Bioactive Materials. A member of the council of “Nanobiology Academic Subgroup, Biophysical Society of China”. A member of the youth committee of “Chinese Society for Biomaterials”. “Young Scientist Award” by “Chinese Society for Biomaterials” in 2018, “Young Innovator Award in Nanobiotechnology” by Nano Research in 2018, “First Prize of Ministerial and Provincial-Level Science and Technology Awards” in 2020.

1.Huan Peng#,Yan Li#, Weihong Ji, Ruichen Zhao, Zhiguo Lu, Jie Shen, Yanyue Wu, Jianze Wang, Qiulian Hao, Jingwen Wang, Wenli Wang, Jun Yang,  Xin Zhang*. Nanocarriers Based on Therapeutic Exosomes for Synergistic Treatment of Parkinson’s Disease. ACS Nano, 2022,16(1): 869-884. (IF=15.811)

2. Jie Shen#, Zhiguo Lu#, Jianze Wang, Qiulian Hao, Weihong Ji, Yanyue Wu, Huan Peng, Ruichen Zhao, Jun Yang, Yan Li, Zhuyan Shi, Xin Zhang*. Traceable Nano-Biohybrid Complexes by One-Step Synthesis as CRISPR-Chem Vectors for Neurodegenerative Diseases Synergistic Treatment. Advanced Materials, 2021, 33(27): 2101993. (IF=30.254)

3. Weihong Ji#, Yan Li#, Huan Peng, Ruichen Zhao, Jie Shen, Yanyue Wu, Jianze Wang, Qiulian Hao, Zhiguo Lu, Jun Yang, Xin Zhang*. Self-catalytic Small Interfering RNA Nanocarriers for Synergistic Treatment of Neurodegenerative Diseases. Advanced Materials, 2021,34(1): 2105711. (IF=30.254)

4. Linying Liu#,Yan Li#, Huan Peng, Ruiyuan Liu,Weihong Ji, Zhuyan Shi, Jie Shen, Guanghui Ma, Xin Zhang*. Targeted exosome coating gene-chem nanocomplex as “nanoscavenger” for clearing α-synuclein and immune activation of Parkinson's disease. Science Advances, 2020, 6(50):  eaba3967. (IF=16.450)

5. Ruiyuan Liu#, Jun Yang#, Linying Liu, Zhiguo Lu, Zhuyan Shi, Weihong Ji, Jie Shen, Xin Zhang*. An ‘Amyloid-β Cleaner’ for the Treatment of Alzheimer’s Disease by Normalizing Microglial Dysfunction. Advanced Science, 2020, 7: 1901555-1901567. (IF=17.835)

6. Chenmeng Qiao#, Jun Yang#, Qi Shen, Ruiyuan Liu, Yanhui Li, Yuanjie Shi, Jingli Chen, Yanqin Shen, Zuobing Xiao, Jie Weng*, Xin Zhang*, Traceable Nanoparticles with Dual Targeting and ROS Response for RNAi-Based Immunochemotherapy of Intracranial Glioblastoma Treatment, Advanced Materials, 2018, 30: 1705054. (IF=30.254)

7. Yan Li, Yanhui Li, Weihong Ji, Zhiguo Lu, Linying Liu, Yuanjie Shi, Guanghui Ma, Xin Zhang*. Positively Charged Polyprodrug Amphiphiles with Enhanced Drug Loading and Reactive Oxygen Species-Responsive Release Ability for Traceable Synergistic Therapy. JACS, 2018, 140: 4164-4171. (IF=15.801)

8. Zhiguo Lu#, Yan Li#, Yuanjie Shi, Yanhui Li, Zuobing Xiao, Xin Zhang*.Traceable Nanoparticles with Spatiotemporally Controlled Release Ability for 5 Synergistic Glioblastoma Multiforme Treatment. Advanced Functional Materials, 2017, 27: 1703967. (IF=18.125)

9. Ran Zhang#, Yan Li#, Bingbing Hu, Zhiguo Lu, Jinchao Zhang*, Xin Zhang*. Traceable Nanoparticle Delivery of Small Interfering RNA and Retinoic Acid with Temporally Release Ability to Control Neural Stem Cell Differentiation for Alzheimer's Disease Therapy. Advanced Materials, 2016, 28: 6345-6352. (IF=30.254)

10. Heng Deng#, Fengying Dai#, Guanghui Ma, Xin Zhang*. Theranostic Gold Nanomicelles made from Biocompatible Comb-like Polymers for Thermochemotherapy and Multifunctional Imaging with Rapid Clearance. Advanced Materials, 2015, 27: 3645-3653. (IF=30.254)