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# LIU Ruitian
  • Title:
    Professor
  • Subject:
    Biotech Drugs
  • Email:
    rtliu@ipe.ac.cn
  • Address:
    No. 1, BeiErJie, ZhongGuanCun, Haidian District, Beijing
Resume

Prof. Ruitian Liu received his PhD in microbiology at Shandong University and completed postdoctoral work at Arizona State University. He is a professor of biotech drugs at Institute of Process Engineering, Chinese Academy of Science after working at Tsinghua University from 2005 to 2012. The research at the Liu’s lab focuses on the development of biotechnology such as cell reprogramming and gene therapy, and genetic engineering antibodies, peptides and vaccines to treat Alzheimer's Disease (AD), Parkinson's Disease (PD), Huntingdon's Disease (HD), Amyotrophic lateral sclerosis (ALS), cancer, autoimmune diseases and other major human diseases. Dr. Liu is also interested in exploring the mechanism underlying the important biological processes such as occurrence and development of neurodegenerative diseases, amyloid aggregation and cytotoxicity, neuroimmune response, allergy, and neuroinflammation. Some biotech drugs are under investigation for their safety and would be tested in clinical soon.

Publications

1. Shuai Lu, Xi-xiu Xie, Lei Zhao, Bin Wang, Jie Zhu, Ting-rui Yang, Guang-wen Yang, Mei Ji, Cui-ping Lv, Jian Xue, Er-hei Dai, Xi-ming Fu, Dong-qun Liu, Lun Zhang, Sheng-jie Hou, Xiao-lin Yu, Yu-ling Wang, Hui-xia Gao, Xue-han Shi, Chang-wen Ke, Bi-xia Ke, Chun-guo Jiang*, Rui-tian Liu*. The immunodominant and neutralization linear epitopes for SARS-CoV-2. Cell Reports. 2021, 34: 108666.

2. Ling-xiao Zhang, Ying-bo Jia, Ya-ru Huang, Hui-na Liu, Xia-mei Sun, Ting Cai*, Rui-tian Liu*, and Zhi Ping Xu*. Efficient delivery of clay-based nanovaccines to the mouse spleen promotes potent anti-tumor immunity for both prevention and treatment of lymphoma. Nano Research, 2021, 14: 1326-1334.

3. Ling-xiao Zhang, Ying-bo Jia, Xia-mei Sun, Xiao-ge Liu, Mingdong Dong, Zhiping Xu*, Rui-tian Liu*. Nanovaccine’s Rapid Induction of Anti-tumor Immunity Significantly Improves Malignant Cancer Immunotherapy. Nano Today. 2020, 35: 100923.

4. Lun Zhang, Xiao-ge Liu, Dong-qun Liu, Xiao-lin Yu, Ling-xiao Zhang, Jie Zhu, Shuai Lu*, Rui-tian Liu*. A conditionally releasable “don’t eat me” CD47 signal facilitates microglia-targeted drug delivery for the treatment of Alzheimer's disease. Advanced Functional Materials. 2020, 30: 1910691.

5. Mei ji, Xi-xiu Xie, Dong-qun Liu, Shuai Lu, Ling-Xiao Zhang, Ya-ru Huang, Rui-tian Liu*. Engineered Hepatitis B core Virus-Like Particle carrier for precise and personalized Alzheimer’s disease vaccines via SpyCatcher/SpyTag technology. Applied Materials Today. 2020, 19: 100575.

6. Xiao-lin Yu, Jie Zhu, Xiang-meng Liu, Peng-xin Xu, Yue Zhang, Rui-tian Liu*. Vaccines targeting the primary amino acid sequence and conformational epitope of amyloid-β had distinct effects on neuropathology and cognitive deficits in EAE/AD mice. Br J Pharmacol. 2020, 177: 2860-2871.

7. Ya-ru Huang, Xi-xiu Xie, Mei Ji, Xiao-lin Yu, Jie Zhu, Ling-xiao Zhang, Xiao-ge Liu, Wei C, Gang Li*, Rui-tian Liu*. Naturally occurring autoantibodies against α-synuclein rescues memory and motor deficits and attenuates α-synuclein pathology in mouse model of Parkinson's disease. Neurobiol Dis. 2019, 124: 202-217.

8. Mei Ji, Xi-xiu Xie, Dong-qun Liu, Xiao-lin Yu, Yue Zhang, Ling-xiao Zhang, Shao-wei Wang, Ya-ru Huang, Rui-tian Liu*. Hepatitis B core VLP-based mis-disordered tau vaccine elicits strong immune response and alleviates cognitive deficits and neuropathology progression in Tau.P301S mouse model of Alzheimer's disease and frontotemporal dementia. Alzheimers Res Ther. 2018, 10(1): 55.

9. Dong-qun Liu, Shuai Lu, Ling-xiao Zhang, Mei Ji, Shu-ying Liu, Shao-wei Wang, Rui-tian Liu*. An indoleamine 2, 3-dioxygenase siRNA nanoparticle-coated and Trp2-displayed recombinant yeast vaccine inhibits melanoma tumor growth in mice. J Control Release. 2018, 273: 1-12.

10. Ling-xiao Zhang, Xi-xiu Xie, Dong-qun Liu, Zhiping Xu*, Rui-tian Liu*. Efficient co-delivery of neo-epitopes using dispersion-stable layered double hydroxide nanoparticles for enhanced melanoma immunotherapy. Biomaterials. 2018, 174: 54-66.

CONTACT US

  • CONTACT US 86-10-82544817
  • CONTACT US 62551257
  • CONTACT US ghb@ipe.ac.cn
  • CONTACT US Institute of Process Engineering,Chinese Academy of Sciences,1 North 2nd Street, Zhongguancun, Haidian District, Beijing 100190, PR China

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