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# DU Yuguang
  • Title:
    Professor
  • Subject:
    Glycobiology，Glycobioengineering
  • Email:
    ygdu@ipe.ac.cn
  • Address:
    No. 1, BeiErJie, ZhongGuanCun, Haidian District, Beijing
Resume

Yuguang Du, Professor, Principle investigator of the Glyco-bioengineering Group at Institute of Process Engineering (CAS), Vice Director of National Engineering Research Center for Biotechnology (Beijing), Chairman of Glyco-biotechnology Committee of Chinese biotechnology Society. Prof. Du and his co-workers have completed and are taking charge of more than twenty scientific research projects such as tackling key problems for “National Ninth/Tenth/Eleventh Five-year Plan”, National “863” Plan Project, National Key R&D Program of China, and National Natural Science Foundation. He has received five awards in provincial, ministerial or municipal levels, published more than 240 papers in the academic journals of China and abroad, participated in publishing seven books, applied more than one hundred patents (over 40 granted), have over fifty PhD and master students. Discovered oligosacchrides have been adapted for commercialization and yielding considerable social and commercial benefits. Developed oligosacchaides products include three health food products (All three has been certified by State Food and Drug Adminstration of the People’s Republic of China and begun to be industrialized), five bio-pesticide products, and feed additives (it has been certificated by the Ministry of Agriculture of the People’s Republic of China). 

Research area:

Focusing on developing new technology of oligosaccharide analysis, separation and preparation, establishing natural oligosaccharides library. Exploring the modulation mechanisms of various oligosaccharides to the development and immunity of animals and plants. Developing new techniques on the oligosaccharide engineering, oligosaccharide health products, bio-pesticides, and feed additives. Based on microfluidic chip technologies we have developed rapid, sensitive, high-throughput portable on-site nucleic acid detection equipment and a series of kit products; have constructed tumor migration- invasion organ-on-chip using tumor and vascular cells; colorectal organ-on-chip which could realize cycle peristalsis, co-culture of intestinal bacteria and human cells; and vascular chips that simulate the physiological and pathological changes of the vascular glycocalyx under high blood glucose condition
Publications

1. Junping Zheng, Xubing Yuan, Gong Cheng, Siming Jiao, Cui Feng, Xiaoming Zhao, Heng Yin, Yuguang Du, Hongtao Liu. Chitosan oligosaccharides improve the disturbance in glucose metabolism and reverse the dysbiosis of gut microbiota in diabetic mice, Carbohydrate Polymers, 2018, 190: 77-86.

2. Jinhua Wei, Zhuo A. Wang, Bing Wang, Marefa Jahan, Zhongfu Wang, Peter C. Wynn & Yuguang Du. Characterization of porcine milk oligosaccharides over lactation between primiparous and multiparous female pigs, Scientific reports, 2018, 8: 4688-4704.

3. Chen Zhang, Siming Jiao, Zhuo A. Wang and Yuguang Du. Exploring Effects of Chitosan Oligosaccharides on Mice Gut Microbiota in in vitro Fermentation and Animal Model, Frontiers in Microbiology, 2018,9: 2388-2399.

4. Guiqiang Zhang, Jing Liu, Ruilian Li, Siming Jiao, Cui Feng, Zhuo A. Wang and Yuguang Du. Conjugation of Inulin Improves Anti-Biofilm Activity of Chitosan, Mar. Drugs, 2018, 16:151-164.

5. Junping Zheng, Gong Cheng, Qiongyu L, Siming Jiao, Cui Feng, Xiaoming Zhao, Heng Yin,  Yuguang Du and Hongtao Liu. Chitin Oligosaccharide Modulates Gut Microbiota and Attenuates High-Fat-Diet-Induced Metabolic Syndrome in Mice, Mar. Drugs, 2018, 16: 66-83. (IF 4.186)

6. Yibo Bai, Junping Zheng, Xubing Yuan, Siming Jiao, Cui Feng, Yuguang Du, Hongtao Liu and Lanyan Zheng. Chitosan Oligosaccharides Improve Glucolipid Metabolism Disorder in Liver by Suppression of Obesity-Related Inflammation and Restoration of Peroxisome Proliferator-Activated Receptor Gamma (PPAR), Mar. Drugs, 2018, 16: 455-470.

7. Qingsong Xu, Chen Qu, Jin Wan, Gong Cheng, Wen Yang, Changhao Gong, Jun He and Yuguang Du. Effect of dietary chitosan oligosaccharide supplementation on the pig ovary transcriptome, RSC Advances, 2018, 8: 13266-13273.

8. Pengfei Zhang, Xianghua Yuan, Yuguang Du and Jian-Jun Li. Heterologous expression and biochemical characterization of a GHF9 endoglucanase from the termite Reticulitermes speratus in Pichia pastoris, BMC Biotechnology, 2018, 18(1):35-44.

9. Xianghua Yuan, Pengfei Zhang, Siming Jiao, Yuguang Du, Jian-Jun Li. Overexpression and biochemical characterization of a recombinant psychrophilic endocellulase from Pseudoalteromonas sp. DY3, International Journal of Biological Macromolecules, 2018, 116: 100-105.

CONTACT US

  • CONTACT US 86-10-82544817
  • CONTACT US 62551257
  • CONTACT US ghb@ipe.ac.cn
  • CONTACT US Institute of Process Engineering,Chinese Academy of Sciences,1 North 2nd Street, Zhongguancun, Haidian District, Beijing 100190, PR China

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